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Jun 25 11 3:48 PM

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Does Long-Term Aspirin Use Have Any Effect On Helicobacter pylori Eradication?

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From the Department of Gastroenterology (hsg, md, gku), Baskent University Faculty of Medicine, Konya, Turkey; Departments of Gastroenterology (me) and Cardiology (ms), Konya Research and Training Hospital, Konya, Turkey; and Department of Gastroenterology (uy), Baskent University Faculty of Medicine, Ankara, Turkey.

Abstract

INTRODUCTION:

: Antimicrobial resistance has decreased eradication rates for Helicobacter pylori infection, and recent reports from different countries report eradication rates lower than 80% with triple therapy. The aim of this pilot study was to investigate the efficacy of standard triple eradication regimen in long-term aspirin users.

METHOD:

: The study population consisted of 77 aspirin using patients with dyspeptic symptoms and 79 age- and sex-matched dyspeptic patients without aspirin use as a control group. Both the study group and control patients were given lansoprazole (30 mg twice a day), clarithromycin (500 mg twice a day) and amoxicillin (1 g twice a day) (LCA) for 14 days as the eradication regimen. Patients on the study group were allowed to take aspirin during the eradication regimen (LCAAsp). Eradication was defined as the absence of H pylori as assessed with the C-urea breath test and H pylori stool antigen test 8 weeks after the end of the antimicrobial therapy.

RESULTS:

: The H pylori eradication rate in the LCAAsp group was 64/77 [83%, 95% confidence interval (CI): 79%-94%] with intention-to-treat (ITT) analysis and 64/75 (85%, 95% CI: 82%-96%) with per protocol (PP) analysis, and the H pylori eradication rate in the LCA group was 42/79 (53%, 95% CI: 43%-65%) with ITT analysis and 42/75 (56%, 95% CI: 46%-68%) with PP analysis. The difference between the groups both with ITT analysis and with PP analysis was statistically significant (P < 0.05).

CONCLUSION:

: These data suggest that H pylori eradication rate with standard triple eradication regimen is significantly higher among long-term aspirin users than in controls.
PMID:
21642817
[PubMed - in process]