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Apr 25 11 10:53 AM

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Melatonin reduces the severity of experimental amoebiasis

Aline C Franca-Botelho email, Juliana L Franca email, Fabricio MS Oliveira email, Eduardo L Franca email, Adenilda C Honorio-Franca email, Marcelo V Caliari email and Maria A Gomes email
Parasites & Vectors 2011, 4:62doi:10.1186/1756-3305-4-62

Published: 18 April 2011

Abstract (provisional)


Background

Melatonin has immunomodulatory effects but very little is known about its influence in protozoan infections, such as Entamoeba histolytica, which causes amoebiasis, a disease with significant morbidity and mortality. In this study, we evaluated the effects of exogenous melatonin interference in experimental amoebiasis and on interactions between human blood cells and E. histolytica trophozoites.